BRCA1 Antibody
| Code | Size | Price |
|---|
| PSI-58-979-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Breast cancer type 1 susceptibility protein, 632-, RING finger protein 53, BRCA1, RNF53
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a nuclear phosphoprotein that plays a
role in maintaining genomic stability, and it also acts as a tumor
suppressor. The encoded protein combines with other tumor
suppressors, DNA damage sensors, and signal transducers to form a
large multi-subunit protein complex known as the BRCA1-associated
genome surveillance complex (BASC). This gene product associates
with RNA polymerase II, and through the C-terminal domain, also
interacts with histone deacetylase complexes. This protein thus
plays a role in transcription, DNA repair of double-stranded
breaks, and recombination. Mutations in this gene are responsible
for approximately 40% of inherited breast cancers and more than 80%
of inherited breast and ovarian cancers. Alternative splicing plays
a role in modulating the subcellular localization and physiological
function of this gene. Many alternatively spliced transcript
variants, some of which are disease-associated mutations, have been
described for this gene, but the full-length natures of only some
of these variants has been described. A related pseudogene, which
is also located on chromosome 17, has been identified. [provided by
RefSeq].
Background References:
- Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Fabbro, M., et al. J. Biol. Chem. 279(30):31251-31258(2004)
- Ouchi, M., et al. J. Biol. Chem. 279(19):19643-19648(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This BRCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-472 amino acids from the N-terminal region of human BRCA1.
NCBI Gene ID #:
672
NCBI Official Name:
Breast cancer type 1 susceptibility protein
NCBI Official Symbol:
BRCA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
208 kDa
Protein Accession #:
P38398
Protein GI Number:
728984
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P38398
User NOte:
Optimal dilutions for each application to be determined by the researcher.