UBA7 Antibody
| Code | Size | Price |
|---|
| PSI-57-551-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog, UBA7, UBE1L, UBE2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The modification of proteins with ubiquitin is an
important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three
classes of enzymes: ubiquitin-activating enzymes, or E1s,
ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E1
ubiquitin-activating enzyme family. The encoded enzyme is a
retinoid target that triggers promyelocytic leukemia (PML)/retinoic
acid receptor alpha (RARalpha) degradation and apoptosis in acute
promyelocytic leukemia, where it is involved in the conjugation of
the ubiquitin-like interferon-stimulated gene 15 protein. [provided
by RefSeq].
Background References:
- Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
- Morgan, A.R., et al. Hum. Immunol. 71(6):602-609(2010)
- Feng, Q., et al. Mol. Cancer Ther. 7(12):3780-3788(2008)
- Durfee, L.A., et al. J. Biol. Chem. 283(35):23895-23902(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the N-terminal region of human UBA7.
NCBI Gene ID #:
7318
NCBI Official Name:
Ubiquitin-like modifier-activating enzyme 7
NCBI Official Symbol:
UBA7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
112 kDa
Protein Accession #:
P41226
Protein GI Number:
215273977
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P41226
User NOte:
Optimal dilutions for each application to be determined by the researcher.