INHBA Antibody
| Code | Size | Price |
|---|
| PSI-55-651-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The inhibin beta A subunit joins the alpha subunit to form
a pituitary FSH secretion inhibitor. Inhibin has been shown to
regulate gonadal stromal cell proliferation negatively and to have
tumor-suppressor activity. In addition, serum levels of inhibin
have been shown to reflect the size of granulosa-cell tumors and
can therefore be used as a marker for primary as well as recurrent
disease. Because expression in gonadal and various extragonadal
tissues may vary severalfold in a tissue-specific fashion, it is
proposed that inhibin may be both a growth/differentiation factor
and a hormone. Furthermore, the beta A subunit forms a homodimer,
activin A, and also joins with a beta B subunit to form a
heterodimer, activin AB, both of which stimulate FSH secretion.
Finally, it has been shown that the beta A subunit mRNA is
identical to the erythroid differentiation factor subunit mRNA and
that only one gene for this mRNA exists in the human genome.
Background References:
- Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
- Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :
- Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA.
NCBI Gene ID #:
3624
NCBI Official Name:
Inhibin beta A chain
NCBI Official Symbol:
INHBA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
P08476
Protein GI Number:
124279
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Cell Cycle,Signal Transduction
Swissprot #:
P08476
User NOte:
Optimal dilutions for each application to be determined by the researcher.