LGMN Antibody
| Code | Size | Price |
|---|
| PSI-60-798-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a cysteine protease that has a strict
specificity for hydrolysis of asparaginyl bonds. This enzyme may be
involved in the processing of bacterial peptides and endogenous
proteins for MHC class II presentation in the lysosomal/endosomal
systems. Enzyme activation is triggered by acidic pH and appears to
be autocatalytic. Protein expression occurs after monocytes
differentiate into dendritic cells. A fully mature, active enzyme
is produced following lipopolysaccharide expression in mature
dendritic cells. Overexpression of this gene may be associated with
the majority of solid tumor types. This gene has a pseudogene on
chromosome 13. Several alternatively spliced transcript variants
have been described, but the biological validity of only two has
been determined. These two variants encode the same isoform.
Background References:
- Clerin, V., et al. Atherosclerosis 201(1):53-66(2008)
- Liu, Z., et al. Mol. Cell 29(6):665-678(2008)
- Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
- Dusso, A.S., et al. Am. J. Physiol. Renal Physiol. 289 (1), F8-F28 (2005) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey
Immunogen:
This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.
NCBI Gene ID #:
5641
NCBI Official Name:
Legumain
NCBI Official Symbol:
LGMN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
Protein Accession #:
Q99538
Protein GI Number:
2842759
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Immunology,Obesity,Signal Transduction
Swissprot #:
Q99538
User NOte:
Optimal dilutions for each application to be determined by the researcher.