NFKB Antibody
| Code | Size | Price |
|---|
| PSI-60-327-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a 105 kD protein which can undergo
cotranslational processing by the 26S proteasome to produce a 50 kD
protein. The 105 kD protein is a Rel protein-specific transcription
inhibitor and the 50 kD protein is a DNA binding subunit of the
NF-kappa-B (NFKB) protein complex. NFKB is a transcription
regulator that is activated by various intra- and extra-cellular
stimuli such as cytokines, oxidant-free radicals, ultraviolet
irradiation, and bacterial or viral products. Activated NFKB
translocates into the nucleus and stimulates the expression of
genes involved in a wide variety of biological functions.
Inappropriate activation of NFKB has been associated with a number
of inflammatory diseases while persistent inhibition of NFKB leads
to inappropriate immune cell development or delayed cell growth.
Two transcript variants encoding different isoforms have been found
for this gene.
Background References:
- Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010)
- Song, C., et al. Virology 407(2):268-280(2010)
- Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010)
- Kingeter, L.M., et al. J. Immunol. 185(8):4520-4524(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Immunogen:
This NFKB(p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB(p105).
NCBI Gene ID #:
4790
NCBI Official Name:
Nuclear factor NF-kappa-B p105 subunit
NCBI Official Symbol:
NFKB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
105 kDa
Protein Accession #:
P19838
Protein GI Number:
21542418
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Immunology,Signal Transduction
Swissprot #:
P19838
User NOte:
Optimal dilutions for each application to be determined by the researcher.