CD130 Antibody
| Code | Size | Price |
|---|
| PSI-55-632-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130, IL6ST
Application Note:
For WB starting dilution is: 1:2000
For IHC-P starting dilution is: 1:25
For IHC-P starting dilution is: 1:25
Background:
The protein encoded by this gene is a signal transducer
shared by many cytokines, including interleukin 6 (IL6), ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and
oncostatin M (OSM). This protein functions as a part of the
cytokine receptor complex. The activation of this protein is
dependent upon the binding of cytokines to their receptors. vIL6, a
protein related to IL6 and encoded by the Kaposi sarcoma-associated
herpesvirus, can bypass the interleukin 6 receptor (IL6R) and
directly activate this protein. Knockout studies in mice suggest
that this gene plays a critical role in regulating myocyte
apoptosis. Alternatively spliced transcript variants encoding
distinct isoforms have been described. A related pseudogene has
been identified on chromosome 17.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Goette, N.P., et al. Exp. Hematol. 38(10):868-876(2010)
- Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) :
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CD130 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 871-899 amino acids from the C-terminal region of human CD130.
NCBI Gene ID #:
3572
NCBI Official Name:
Interleukin-6 receptor subunit beta
NCBI Official Symbol:
IL6ST
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
104 kDa
Protein Accession #:
P40189
Protein GI Number:
215273999
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Immunology,Signal Transduction
Swissprot #:
P40189
User NOte:
Optimal dilutions for each application to be determined by the researcher.