TNFR-S274 Antibody
| Code | Size | Price |
|---|
| PSI-55-666-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis factor-binding protein 1, TBPI, TNFRSF1A, TNFAR, TNFR1
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the
TNF-receptor superfamily. This protein is one of the major
receptors for the tumor necrosis factor-alpha. This receptor can
activate NF-kappaB, mediate apoptosis, and function as a regulator
of inflammation. Antiapoptotic protein BCL2-associated athanogene 4
(BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to
interact with this receptor, and thus play regulatory roles in the
signal transduction mediated by the receptor. Germline mutations of
the extracellular domains of this receptor were found to be
associated with the autosomal dominant periodic fever syndrome. The
impaired receptor clearance is thought to be a mechanism of the
disease.
Background References:
- Giroux, S., et al. Bone 47(5):975-981(2010)
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Wolanska, M., et al. Ginekol. Pol. 81(6):431-434(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TNFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from human TNFR.
NCBI Gene ID #:
7132
NCBI Official Name:
Tumor necrosis factor receptor superfamily member 1A
NCBI Official Symbol:
TNFRSF1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
P19438
Protein GI Number:
135959
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Immunology,Signal Transduction,
Swissprot #:
P19438
User NOte:
Optimal dilutions for each application to be determined by the researcher.