PIG3 Antibody
| Code | Size | Price |
|---|
| PSI-60-424-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Quinone oxidoreductase PIG3, 1---, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein, TP53I3, PIG3
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is similar to
oxidoreductases, which are enzymes involved in cellular responses
to oxidative stresses and irradiation. This gene is induced by the
tumor suppressor p53 and is thought to be involved in p53-mediated
cell death. It contains a p53 consensus binding site in its
promoter region and a downstream pentanucleotide microsatellite
sequence. P53 has been shown to transcriptionally activate this
gene by interacting with the downstream pentanucleotide
microsatellite sequence. The microsatellite is polymorphic, with a
varying number of pentanucleotide repeats directly correlated with
the extent of transcriptional activation by p53. It has been
suggested that the microsatellite polymorphism may be associated
with differential susceptibility to cancer. At least two transcript
variants encoding the same protein have been found for this gene.
Background References:
- Kotsinas, A., et al. Oncogene 29 (37), 5220 (2010) :
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Lee, J.H., et al. Oncogene 29(10):1431-1450(2010)
- Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PIG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the C-terminal region of human PIG3.
NCBI Gene ID #:
9540
NCBI Official Name:
Quinone oxidoreductase PIG3
NCBI Official Symbol:
TP53I3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
36 kDa
Protein Accession #:
Q53FA7
Protein GI Number:
76789665
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Obesity
Swissprot #:
Q53FA7
User NOte:
Optimal dilutions for each application to be determined by the researcher.