BARD1 Antibody
| Code | Size | Price |
|---|
| PSI-55-322-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Application Note:
For WB starting dilution is: 1:1000
Background:
BARD1 is a protein which interacts with the
N-terminal region of BRCA1. In addition to its ability to bind
BRCA1 in vivo and in vitro, it shares homology with the 2 most
conserved regions of BRCA1: the N-terminal RING motif and the
C-terminal BRCT domain. The RING motif is a cysteine-rich sequence
found in a variety of proteins that regulate cell growth, including
the products of tumor suppressor genes and dominant protooncogenes.
This protein also contains 3 tandem ankyrin repeats. The
BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid
substitutions in BRCA1, implying that the formation of a stable
complex between these proteins may be an essential aspect of BRCA1
tumor suppression. This protein may be the target of oncogenic
mutations in breast or ovarian cancer.
Background References:
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Dizin, E., et al. Int. J. Biochem. Cell Biol. 42(5):693-700(2010)
- Irminger-Finger, I. Gynecol. Oncol. 117(2):211-215(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This BARD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1.
NCBI Gene ID #:
580
NCBI Official Name:
BRCA1-associated RING domain protein 1
NCBI Official Symbol:
BARD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
Q99728
Protein GI Number:
116241265
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Obesity
Swissprot #:
Q99728
User NOte:
Optimal dilutions for each application to be determined by the researcher.