LRP2 Antibody
| Code | Size | Price |
|---|
| PSI-62-144-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Low-density lipoprotein receptor-related protein 2, LRP-2, Glycoprotein 330, gp330, Megalin, LRP2
Application Note:
For IHC-P starting dilution is: 1:50~100
Background:
Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).
Background References:
- Christensen, E.I., et al., Nat. Rev. Mol. Cell Biol. 3(4):256-266 (2002).
- Hjalm, G., et al., Eur. J. Biochem. 239(1):132-137 (1996).
- Farquhar, M.G., et al., J. Am. Soc. Nephrol. 6(1):35-47 (1995).
- Kounnas, M.Z., et al., J. Biol. Chem. 270(22):13070-13075 (1995).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This LRP2 (Megalin) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4626-4655 amino acids from the C-terminal region of human LRP2 (Megalin).
NCBI Gene ID #:
4036
NCBI Official Name:
Low-density lipoprotein receptor-related protein 2
NCBI Official Symbol:
LRP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
522 kDa
Protein Accession #:
P98164
Protein GI Number:
160332309
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Cell Cycle,Obesity,Signal Transduction
Swissprot #:
P98164
User NOte:
Optimal dilutions for each application to be determined by the researcher.