SDHB Antibody
| Code | Size | Price |
|---|
| PSI-60-810-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip, SDHB, SDH, SDH1
Application Note:
For WB starting dilution is: 1:1000
Background:
Complex II of the respiratory chain, which is specifically
involved in the oxidation of succinate, carries electrons from FADH
to CoQ. The complex is composed of four nuclear-encoded subunits
and is localized in the mitochondrial inner membrane. The
iron-sulfur subunit is highly conserved and contains three
cysteine-rich clusters which may comprise the iron-sulfur centers
of the enzyme. Sporadic and familial mutations in this gene result
in paragangliomas and pheochromocytoma, and support a link between
mitochondrial dysfunction and tumorigenesis.
Background References:
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Cerecer-Gil, N.Y., et al. Clin. Cancer Res. 16(16):4148-4154(2010)
- Schimke, R.N., et al. Am. J. Med. Genet.152A (6), 1531-1535 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
Immunogen:
This SDHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.
NCBI Gene ID #:
6390
NCBI Official Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
NCBI Official Symbol:
SDHB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
Protein Accession #:
P21912
Protein GI Number:
20455488
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Obesity,Signal Transduction
Swissprot #:
P21912
User NOte:
Optimal dilutions for each application to be determined by the researcher.