CYP2R1 Antibody
| Code | Size | Price |
|---|
| PSI-63-273-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.
Background References:
- Ramos-Lopez,E., Diabetes Obes Metab 10 (8), 683-685 (2008)
- Strushkevich,N., J. Mol. Biol. 380 (1), 95-106 (2008)
- Ramos-Lopez,E., Diabetes Metab. Res. Rev. 23 (8), 631-636 (2007)
- Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-496 amino acids from the C-terminal region of human CYP2R1.
NCBI Gene ID #:
120227
NCBI Official Name:
Vitamin D 25-hydroxylase
NCBI Official Symbol:
CYP2R1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
Q6VVX0
Protein GI Number:
62286619
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Cell Cycle,Obesity,Signal Transduction
Swissprot #:
Q6VVX0
User NOte:
Optimal dilutions for each application to be determined by the researcher.