VAV1 Antibody
| Code | Size | Price |
|---|
| PSI-57-309-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Proto-oncogene vav, VAV1, VAV
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this proto-oncogene is a member of
the Dbl family of guanine nucleotide exchange factors (GEF) for the
Rho family of GTP binding proteins. The protein is important in
hematopoiesis, playing a role in T-cell and B-cell development and
activation. This particular GEF has been identified as the specific
binding partner of Nef proteins from HIV-1. Coexpression and
binding of these partners initiates profound morphological changes,
cytoskeletal rearrangements and the JNK/SAPK signaling cascade,
leading to increased levels of viral transcription and replication.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Hollmann, A., et al. Hematol Oncol 28(3):142-150(2010)
- Barda-Saad, M., et al. EMBO J. 29(14):2315-2328(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1.
NCBI Gene ID #:
7409
NCBI Official Name:
Proto-oncogene vav
NCBI Official Symbol:
VAV1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
98 kDa
Protein Accession #:
P15498
Protein GI Number:
13124807
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P15498
User NOte:
Optimal dilutions for each application to be determined by the researcher.