TP63 Antibody
| Code | Size | Price |
|---|
| PSI-57-384-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the p53 family of
transcription factors. An animal model, p63 -/- mice, has been
useful in defining the role this protein plays in the development
and maintenance of stratified epithelial tissues. p63 -/- mice have
several developmental defects which include the lack of limbs and
other tissues, such as teeth and mammary glands, which develop as a
result of interactions between mesenchyme and epithelium. Mutations
in this gene are associated with ectodermal dysplasia, and cleft
lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4
(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT
syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary
syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both
alternative splicing and the use of alternative promoters results
in multiple transcript variants encoding different proteins. Many
transcripts encoding different proteins have been reported but the
biological validity and the full-length nature of these variants
have not been determined.
Background References:
- Du, Z., et al. Cancer Sci. 101(11):2417-2424(2010)
- Lena, A.M., et al. Biochem. Biophys. Res. Commun. 401(4):568-573(2010)
- Miki, D., et al. Nat. Genet. 42(10):893-896(2010)
- Yang, A., et al. PLoS ONE(7), E11572 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from the C-terminal region of human TP63.
NCBI Gene ID #:
8626
NCBI Official Name:
Tumor protein 63
NCBI Official Symbol:
TP63
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
77 kDa
Protein Accession #:
Q9H3D4
Protein GI Number:
57013009
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
Q9H3D4
User NOte:
Optimal dilutions for each application to be determined by the researcher.