RBL1 Antibody
| Code | Size | Price |
|---|
| PSI-60-514-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1, RBL1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is similar in sequence
and possibly function to the product of the retinoblastoma 1 (RB1)
gene. The RB1 gene product is a tumor suppressor protein that
appears to be involved in cell cycle regulation, as it is
phosphorylated in the S to M phase transition and is
dephosphorylated in the G1 phase of the cell cycle. Both the RB1
protein and the product of this gene can form a complex with
adenovirus E1A protein and SV40 large T-antigen, with the SV40
large T-antigen binding only to the unphosphorylated form of each
protein. In addition, both proteins can inhibit the transcription
of cell cycle genes containing E2F binding sites in their
promoters. Due to the sequence and biochemical similarities with
the RB1 protein, it is thought that the protein encoded by this
gene may also be a tumor suppressor. Two transcript variants
encoding different isoforms have been found for this gene.
Background References:
- Jayadeva, G., et al. J. Biol. Chem. 285(39):29863-29873(2010)
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1007-1035 amino acids from the C-terminal region of human RBL1.
NCBI Gene ID #:
5933
NCBI Official Name:
Retinoblastoma-like protein 1
NCBI Official Symbol:
RBL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
121 kDa
Protein Accession #:
P28749
Protein GI Number:
90103515
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P28749
User NOte:
Optimal dilutions for each application to be determined by the researcher.