GPC3 Antibody
| Code | Size | Price |
|---|
| PSI-58-016-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, Secreted glypican-3, GPC3, OCI5
Application Note:
For WB starting dilution is: 1:1000
Background:
Cell surface heparan sulfate proteoglycans are composed of
a membrane-associated protein core substituted with a variable
number of heparan sulfate chains. Members of the glypican-related
integral membrane proteoglycan family (GRIPS) contain a core
protein anchored to the cytoplasmic membrane via a glycosyl
phosphatidylinositol linkage. These proteins may play a role in the
control of cell division and growth regulation. The protein encoded
by this gene can bind to and inhibit the dipeptidyl peptidase
activity of CD26, and it can induce apoptosis in certain cell
types. Deletion mutations in this gene are associated with
Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia
syndrome. Alternative splicing results in multiple transcript
variants.
Background References:
- Lai, J.P., et al. Hepatology 52(5):1680-1689(2010)
- Sakurai, M., et al. Gynecol. Oncol. 119(2):332-336(2010)
- Zynger, D.L., et al. Histopathology 56(6):750-757(2010)
- Davoodi, J., et al. Proteomics 7(13):2300-2310(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human GPC3.
NCBI Gene ID #:
2719
NCBI Official Name:
Glypican-3
NCBI Official Symbol:
GPC3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Protein Accession #:
P51654
Protein GI Number:
1708022
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P51654
User NOte:
Optimal dilutions for each application to be determined by the researcher.