KLKB1 Antibody
| Code | Size | Price |
|---|
| PSI-57-482-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, Plasma kallikrein heavy chain, Plasma kallikrein light chain, KLKB1, KLK3
Application Note:
For WB starting dilution is: 1:1000
Background:
Plasma prekallikrein is a glycoprotein that participates
in the surface-dependent activation of blood coagulation,
fibrinolysis, kinin generation and inflammation. It is synthesized
in the liver and secreted into the blood as a single polypeptide
chain. Plasma prekallikrein is converted to plasma kallikrein by
factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma
kallikrein therefore is composed of a heavy chain and a light chain
held together by a disulphide bond. The heavy chain originates
from the amino-terminal end of the zymogen and contains 4 tandem
repeats of 90 or 91 amino acids. Each repeat harbors a novel
structure called the apple domain. The heavy chain is required for
the surface-dependent pro-coagulant activity of plasma kallikrein.
The light chain contains the active site or catalytic domain of the
enzyme and is homologous to the trypsin family of serine proteases.
Plasma prekallikrein deficiency causes a prolonged activated
partial thromboplastin time in patients.
Background References:
- MacKenzie, J.A., et al. Appl Physiol Nutr Metab 35(4):518-525(2010)
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
- Eeckhoudt, S.L., et al. Thromb. Haemost. 103(4):866-867(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This KLKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 amino acids from the C-terminal region of human KLKB1.
NCBI Gene ID #:
3818
NCBI Official Name:
Plasma kallikrein
NCBI Official Symbol:
KLKB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
71 kDa
Protein Accession #:
P03952
Protein GI Number:
125184
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P03952
User NOte:
Optimal dilutions for each application to be determined by the researcher.