FAP Antibody
| Code | Size | Price |
|---|
| PSI-56-494-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Prolyl endopeptidase FAP, 170 kDa melanoma membrane-bound gelatinase, Dipeptidyl peptidase FAP, Fibroblast activation protein alpha, FAPalpha, Serine integral membrane protease, SIMP, Surface-expressed protease, Seprase, Antiplasmin-cleaving enzyme FAP, soluble form, APCE, 3421-, FAP (HGNC:3590)
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)Ospelt, C., et al. Arthritis Rheum. 62(5):1224-1235(2010) Stremenova, J., et al. Int. J. Oncol. 36(2):351-358(2010) Chen, H., et al. Exp. Mol. Pathol. 87(3):189-194(2009) Dohi, O., et al. Histopathology 55(4):432-440(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FAP antibody is generated from rabbits immunized with the protein of human FAP.
NCBI Gene ID #:
2191
NCBI Official Name:
Prolyl endopeptidase FAP
NCBI Official Symbol:
FAP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
88 kDa
Protein Accession #:
Q12884
Protein GI Number:
292495099
Purification:
This antibody is purified through a protein A column, followed by dialysis against PBS
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
Q12884
User NOte:
Optimal dilutions for each application to be determined by the researcher.