AR Antibody
| Code | Size | Price |
|---|
| PSI-56-955-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Application Note:
For WB starting dilution is: 1:1000
Background:
The androgen receptor gene is more than 90 kb long and
codes for a protein that has 3 major functional domains: the
N-terminal domain, DNA-binding domain, and androgen-binding domain.
The protein functions as a steroid-hormone activated transcription
factor. Upon binding the hormone ligand, the receptor dissociates
from accessory proteins, translocates into the nucleus, dimerizes,
and then stimulates transcription of androgen responsive genes.
This gene contains 2 polymorphic trinucleotide repeat segments that
encode polyglutamine and polyglycine tracts in the N-terminal
transactivation domain of its protein. Expansion of the
polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy
disease). Mutations in this gene are also associated with complete
androgen insensitivity (CAIS). Two alternatively spliced variants
encoding distinct isoforms have been described. [provided by
RefSeq].
Background References:
- Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010)
- Nedelsky, N.B., et al. Neuron 67(6):936-952(2010)
- Panda, B., et al. Gynecol. Endocrinol. (2010) In press :
- Schneider, G., et al. AmGeriatr Psychiatry (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 475-504 amino acids from the Central region of human AR.
NCBI Gene ID #:
367
NCBI Official Name:
Androgen receptor
NCBI Official Symbol:
AR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
99 kDa
Protein Accession #:
P10275
Protein GI Number:
113830
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P10275
User NOte:
Optimal dilutions for each application to be determined by the researcher.