CDKN2B Antibody
| Code | Size | Price |
|---|
| PSI-56-550-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
This gene lies adjacent to the tumor suppressor gene
CDKN2A in a region that is frequently mutated and deleted in a wide
variety of tumors. This gene encodes a cyclin-dependent kinase
inhibitor, which forms a complex with CDK4 or CDK6, and prevents
the activation of the CDK kinases, thus the encoded protein
functions as a cell growth regulator that controls cell cycle G1
progression. The expression of this gene was found to be
dramatically induced by TGF beta, which suggested its role in the
TGF beta induced growth inhibition. Two alternatively spliced
transcript variants of this gene, which encode distinct proteins,
have been reported.
Background References:
- Camacho, C.V., et al. Carcinogenesis 31(10):1889-1896(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)
- Heni, M., et al. Diabetes (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B.
NCBI Gene ID #:
1030
NCBI Official Name:
Cyclin-dependent kinase 4 inhibitor B
NCBI Official Symbol:
CDKN2B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
15 kDa
Protein Accession #:
P42772
Protein GI Number:
1168869
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P42772
User NOte:
Optimal dilutions for each application to be determined by the researcher.