TIMP1 Antibody
| Code | Size | Price |
|---|
| PSI-55-700-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
This gene belongs to the TIMP gene family. The proteins
encoded by this gene family are natural inhibitors of the matrix
metalloproteinases (MMPs), a group of peptidases involved in
degradation of the extracellular matrix. In addition to its
inhibitory role against most of the known MMPs, the encoded protein
is able to promote cell proliferation in a wide range of cell
types, and may also have an anti-apoptotic function. Transcription
of this gene is highly inducible in response to many cytokines and
hormones. In addition, the expression from some but not all
inactive X chromosomes suggests that this gene inactivation is
polymorphic in human females. This gene is located within intron 6
of the synapsin I gene and is transcribed in the opposite
direction.
Background References:
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Lin, C.C., et al. ClinAm Soc Nephrol 5(10):1805-1814(2010)
- Yeh, Y.C., et al. BMC Microbiol. 10, 218 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TIMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-188 amino acids from the C-terminal region of human TIMP1.
NCBI Gene ID #:
7076
NCBI Official Name:
Metalloproteinase inhibitor 1
NCBI Official Symbol:
TIMP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
P01033
Protein GI Number:
135850
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
P01033
User NOte:
Optimal dilutions for each application to be determined by the researcher.