CD8B1 Antibody
| Code | Size | Price |
|---|
| PSI-56-141-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1
Application Note:
For WB starting dilution is: 1:1000
Background:
The CD8 antigen is a cell surface glycoprotein found on
most cytotoxic T lymphocytes that mediates efficient cell-cell
interactions within the immune system. The CD8 antigen, acting as a
coreceptor, and the T-cell receptor on the T lymphocyte recognize
antigens displayed by an antigen presenting cell (APC) in the
context of class I MHC molecules. The functional coreceptor is
either a homodimer composed of two alpha chains, or a heterodimer
composed of one alpha and one beta chain. Both alpha and beta
chains share significant homology to immunoglobulin variable light
chains. This gene encodes the CD8 beta chain isoforms. Multiple
alternatively spliced transcript variants encoding distinct
membrane associated or secreted isoforms have been described. A
pseudogene, also located on chromosome 2, has been identified.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Chen, M.L., et al. Eur. J. Immunol. 39(12):3423-3435(2009)
- Thakral, D., et al. J. Immunol. 180(11):7431-7442(2008)
- Stove, V., et al. J. Virol. 79(17):11422-11433(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CD8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-167 amino acids from the C-terminal region of human CD8B1.
NCBI Gene ID #:
926
NCBI Official Name:
T-cell surface glycoprotein CD8 beta chain
NCBI Official Symbol:
CD8B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
P10966
Protein GI Number:
116032
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology
Swissprot #:
P10966
User NOte:
Optimal dilutions for each application to be determined by the researcher.