GPNMB Antibody
| Code | Size | Price |
|---|
| PSI-59-048-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB
Application Note:
For WB starting dilution is: 1:500
Background:
The protein encoded by this gene is a type I transmembrane
glycoprotein which shows homology to the pMEL17 precursor, a
melanocyte-specific protein. GPNMB shows expression in the lowly
metastatic human melanoma cell lines and xenografts but does not
show expression in the highly metastatic cell lines. GPNMB may be
involved in growth delay and reduction of metastatic potential. Two
transcript variants encoding different isoforms have been found for
this gene.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Williams, M.D., et al. Melanoma Res. 20(3):184-190(2010)
- Hoashi, T., et al. FASEB J. 24(5):1616-1629(2010)
- Rose, A.A., et al. Clin. Cancer Res. 16(7):2147-2156(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GPNMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human GPNMB.
NCBI Gene ID #:
10457
NCBI Official Name:
Transmembrane glycoprotein NMB
NCBI Official Symbol:
GPNMB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
Q14956
Protein GI Number:
61252504
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology
Swissprot #:
Q14956
User NOte:
Optimal dilutions for each application to be determined by the researcher.