PTPRC Antibody
Code | Size | Price |
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PSI-56-003-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an extracellular
domain, a single transmembrane segment and two tandem
intracytoplasmic catalytic domains, and thus belongs to receptor
type PTP. This gene is specifically expressed in hematopoietic
cells. This PTP has been shown to be an essential regulator of T-
and B-cell antigen receptor signaling. It functions through either
direct interaction with components of the antigen receptor
complexes, or by activating various Src family kinases required for
the antigen receptor signaling. This PTP also suppresses JAK
kinases, and thus functions as a regulator of cytokine receptor
signaling. Four alternatively spliced transcripts variants of this
gene, which encode distinct isoforms, have been reported. [provided
by RefSeq].
Background References:
- Heyd, F., et al. Mol. Cell 40(1):126-137(2010)
- Wu, Z., et al. J. Immunol. 185(1):231-238(2010)
- Cui, J., et al. Arthritis Rheum. 62(7):1849-1861(2010)
- Booth, N.J., et al. J. Immunol. 184(8):4317-4326(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PTPRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the N-terminal region of human PTPRC.
NCBI Gene ID #:
5788
NCBI Official Name:
Receptor-type tyrosine-protein phosphatase C
NCBI Official Symbol:
PTPRC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
147 kDa
Protein Accession #:
P08575
Protein GI Number:
33112650
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology,Neuroscience,Signal Transduction
Swissprot #:
P08575
User NOte:
Optimal dilutions for each application to be determined by the researcher.