CD3E Antibody
| Code | Size | Price |
|---|
| PSI-57-098-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is the CD3-epsilon
polypeptide, which together with CD3-gamma, -delta and -zeta, and
the T-cell receptor alpha/beta and gamma/delta heterodimers, forms
the T-cell receptor-CD3 complex. This complex plays an important
role in coupling antigen recognition to several intracellular
signal-transduction pathways. The genes encoding the epsilon, gamma
and delta polypeptides are located in the same cluster on
chromosome 11. The epsilon polypeptide plays an essential role in
T-cell development. Defects in this gene cause immunodeficiency.
This gene has also been linked to a susceptibility to type I
diabetes in women.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Brophy, K., et al. BMC Med. Genet. 11, 76 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey
Immunogen:
This CD3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the C-terminal region of human CD3E.
NCBI Gene ID #:
916
NCBI Official Name:
T-cell surface glycoprotein CD3 epsilon chain
NCBI Official Symbol:
CD3E
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
P07766
Protein GI Number:
1345708
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology,Signal Transduction
Swissprot #:
P07766
User NOte:
Optimal dilutions for each application to be determined by the researcher.