Mouse Mapk8 Antibody
| Code | Size | Price |
|---|
| PSI-57-885-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, Mapk8, Jnk1, Prkm8
Application Note:
For WB starting dilution is: 1:1000
Background:
Mapk8 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4) (By similarity).
Background References:
- Sherrin, T., et al. J. Neurosci. 30(40):13348-13361(2010)
- Morel, C., et al. Mol. Cell. Biol. 30(19):4616-4625(2010)
- Gao, D., et al. J. Biol. Chem. 285(39):29965-29973(2010)
- Han, J.S., et al. Anticancer Res. 30(9):3407-3412(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat, Xenopus
Immunogen:
This Mouse Mapk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the Central region of mouse Mapk8.
NCBI Gene ID #:
26419
NCBI Official Name:
Mitogen-activated protein kinase 8
NCBI Official Symbol:
Mapk8
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
Q91Y86
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology,Signal Transduction
Swissprot #:
Q91Y86
User NOte:
Optimal dilutions for each application to be determined by the researcher.