CD27 Antibody
| Code | Size | Price |
|---|
| PSI-57-238-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor is required for generation
and long-term maintenance of T cell immunity. It binds to ligand
CD70, and plays a key role in regulating B-cell activation and
immunoglobulin synthesis. This receptor transduces signals that
lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins
TRAF2 and TRAF5 have been shown to mediate the signaling process of
this receptor. CD27-binding protein (SIVA), a proapoptotic protein,
can bind to this receptor and is thought to play an important role
in the apoptosis induced by this receptor.
Background References:
- Jiang, J., et al. J. Clin. Immunol. 30(4):566-573(2010)
- Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010)
- Mizuochi, T., et al. J. Interferon Cytokine Res. 30(4):243-252(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human CD27.
NCBI Gene ID #:
939
NCBI Official Name:
CD27 antigen
NCBI Official Symbol:
CD27
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
P26842
Protein GI Number:
269849546
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology,Signal Transduction
Swissprot #:
P26842
User NOte:
Optimal dilutions for each application to be determined by the researcher.