IL12B Antibody
| Code | Size | Price |
|---|
| PSI-55-192-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2, IL12B, NKSF2
Application Note:
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
Background:
IL12B is a subunit of interleukin 12, a cytokine
that acts on T and natural killer cells, and has a broad array of
biological activities. Interleukin 12 is a disulfide-linked
heterodimer composed of the 40 kD cytokine receptor like subunit
encoded by this gene, and a 35 kD subunit encoded by IL12A. This
cytokine is expressed by activated macrophages that serve as an
essential inducer of Th1 cells development. This cytokine has been
found to be important for sustaining a sufficient number of
memory/effector Th1 cells to mediate long-term protection to an
intracellular pathogen. Overexpression of this gene was observed in
the central nervous system of patients with multiple sclerosis
(MS), suggesting a role of this cytokine in the pathogenesis of the
disease. The promoter polymorphism of this gene has been reported
to be associated with the severity of atopic and non-atopic asthma
in children.
Background References:
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Miteva, L.D., et al. Rheumatol. Int. (2010) In press :
- de Heens, G.L., et al. J. Clin. Periodontol. 37(2):129-136(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This IL12B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-290 amino acids from the C-terminal region of human IL12B.
NCBI Gene ID #:
3593
NCBI Official Name:
Interleukin-12 subunit beta
NCBI Official Symbol:
IL12B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
Protein Accession #:
P29460
Protein GI Number:
266320
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Immunology,Signal Transduction
Swissprot #:
P29460
User NOte:
Optimal dilutions for each application to be determined by the researcher.