CRKL Antibody
| Code | Size | Price |
|---|
| PSI-57-110-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Crk-like protein, CRKL
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein kinase containing SH2 and SH3
(src homology) domains which has been shown to activate the RAS and
JUN kinase signaling pathways and transform fibroblasts in a
RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine
kinase, plays a role in fibroblast transformation by BCR-ABL, and
may be oncogenic.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Kim, Y.H., et al. Oncogene 29(10):1421-1430(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Segovis, C.M., et al. J. Immunol. 182(11):6933-6942(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This CRKL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CRKL.
NCBI Gene ID #:
1399
NCBI Official Name:
Crk-like protein
NCBI Official Symbol:
CRKL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
34 kDa
Protein Accession #:
P46109
Protein GI Number:
1169094
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Neuroscience,Signal Transduction
Swissprot #:
P46109
User NOte:
Optimal dilutions for each application to be determined by the researcher.