CTNNB1 Antibody
| Code | Size | Price |
|---|
| PSI-60-609-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is part of a complex of
proteins that constitute adherens junctions (AJs). AJs are
necessary for the creation and maintenance of epithelial cell
layers by regulating cell growth and adhesion between cells. The
encoded protein also anchors the actin cytoskeleton and may be
responsible for transmitting the contact inhibition signal that
causes cells to stop dividing once the epithelial sheet is
complete. Finally, this protein binds to the product of the APC
gene, which is mutated in adenomatous polyposis of the colon.
Mutations in this gene are a cause of colorectal cancer (CRC),
pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer.
Three transcript variants encoding the same protein have been found
for this gene.
Background References:
- Huang, W., et al. Mol. Cell. Biol. 30(19):4575-4594(2010)
- Chairoungdua, A., et al. J. Cell Biol. 190(6):1079-1091(2010)
- Mirza, M.K., et al. J. Exp. Med. 207(8):1675-1685(2010)
- Guo, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 42(7):450-456(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-751 amino acids from the C-terminal region of human CTNNB1.
NCBI Gene ID #:
1499
NCBI Official Name:
Catenin beta-1
NCBI Official Symbol:
CTNNB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
P35222
Protein GI Number:
461854
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Neuroscience,Signal Transduction
Swissprot #:
P35222
User NOte:
Optimal dilutions for each application to be determined by the researcher.