TrkC Antibody

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ProSci
Product Code: PSI-63-145
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-63-145-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Immunohistochemical analysis of paraffin-embedded H. brain section using TrkC Antibody. Antibody was diluted at 1:100 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
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Western blot analysis in U87-MG cell line lysates (35ug/lane).
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Immunohistochemical analysis of paraffin-embedded H. brain section using TrkC Antibody. Antibody was diluted at 1:100 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
Western blot analysis in U87-MG cell line lysates (35ug/lane).

Documents

Further Information

Additional Names:
NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC
Application Note:
For IHC-P starting dilution is: 1:100

For WB starting dilution is: 1:1000
Background:
TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
Background References:
  • McGregor, L.M., et al., Genomics 22(2):267-272 (1994).
  • Shelton, D.L., et al., J. Neurosci. 15 (1 Pt 2), 477-491 (1995).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TrkC antibody is generated from rabbits immunized with a his tag recombinant protein of human TrkC.
NCBI Gene ID #:
4916
NCBI Official Name:
NT-3 growth factor receptor
NCBI Official Symbol:
NTRK3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
94 kDa
Protein Accession #:
Q16288
Protein GI Number:
134035335
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Neuroscience,Signal Transduction
Swissprot #:
Q16288
User NOte:
Optimal dilutions for each application to be determined by the researcher.