EGLN1 Antibody
| Code | Size | Price |
|---|
| PSI-60-009-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Egl nine homolog 1, Hypoxia-inducible factor prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20, EGLN1 (HGNC:1232), C1orf12
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene catalyzes the
post-translational formation of 4-hydroxyproline in
hypoxia-inducible factor (HIF) alpha proteins. HIF is a
transcriptional complex that plays a central role in mammalian
oxygen homeostasis. This protein functions as a cellular oxygen
sensor, and under normal oxygen concentration, modification by
prolyl hydroxylation is a key regulatory event that targets HIF
subunits for proteasomal destruction via the von Hippel-Lindau
ubiquitylation complex. Mutations in this gene are associated with
erythrocytosis familial type 3 (ECYT3).
Background References:
- Aggarwal, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18961-18966(2010)
- Vogel, S., et al. J. Biol. Chem. 285(44):33756-33763(2010)
- Simonson, T.S., et al. Science 329(5987):72-75(2010)
- Thoms, B.L., et al. J. Biol. Chem. 285(27):20472-20480(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This EGLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the C-terminal region of human EGLN1.
NCBI Gene ID #:
54583
NCBI Official Name:
Egl nine homolog 1
NCBI Official Symbol:
EGLN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
Q9GZT9
Protein GI Number:
32129514
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity
Swissprot #:
Q9GZT9
User NOte:
Optimal dilutions for each application to be determined by the researcher.