HIF1A Antibody
Code | Size | Price |
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PSI-60-903-400ul | 400ul | £626.00 |
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8
Application Note:
For WB starting dilution is: 1:1000
Background:
Hypoxia-inducible factor-1 (HIF1) is a transcription
factor found in mammalian cells cultured under reduced oxygen
tension that plays an essential role in cellular and systemic
homeostatic responses to hypoxia. HIF1 is a heterodimer composed of
an alpha subunit and a beta subunit. The beta subunit has been
identified as the aryl hydrocarbon receptor nuclear translocator
(ARNT). This gene encodes the alpha subunit of HIF-1.
Overexpression of a natural antisense transcript (aHIF) of this
gene has been shown to be associated with nonpapillary renal
carcinomas. Two alternative transcripts encoding different isoforms
have been identified.
Background References:
- Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010)
- Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)
- Espinosa, I., et al. Am. J. Surg. Pathol. 34(11):1708-1714(2010)
- Corzo, C.A., et al. J. Exp. Med. 207(11):2439-2453(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This HIF1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-762 amino acids from the C-terminal region of human HIF1A.
NCBI Gene ID #:
3091
NCBI Official Name:
Hypoxia-inducible factor 1-alpha
NCBI Official Symbol:
HIF1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
93 kDa
Protein Accession #:
Q16665
Protein GI Number:
2498017
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity
Swissprot #:
Q16665
User NOte:
Optimal dilutions for each application to be determined by the researcher.