XRCC1 Antibody
| Code | Size | Price |
|---|
| PSI-61-969-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1
Application Note:
For IF starting dilution is: 1:25
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is involved in the
efficient repair of DNA single-strand breaks formed by exposure to
ionizing radiation and alkylating agents. This protein interacts
with DNA ligase III, polymerase beta and poly (ADP-ribose)
polymerase to participate in the base excision repair pathway. It
may play a role in DNA processing during meiogenesis and
recombination in germ cells. A rare microsatellite polymorphism in
this gene is associated with cancer in patients of varying
radiosensitivity.
Background References:
- Lamerdin, J.E., et al. Genomics 25(2):547-554(1995)
- Gyapay, G., et al. Nat. Genet.(2 SPEC NO), 246-339 (1994) :
- Thompson, L.H., et al. Mol. Cell. Biol. 10(12):6160-6171(1990)
- Thompson, L.H., et al. Genomics 5(4):670-679(1989)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.
NCBI Gene ID #:
7515
NCBI Official Name:
DNA repair protein XRCC1
NCBI Official Symbol:
XRCC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
69 kDa
Protein Accession #:
P18887
Protein GI Number:
317373290
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity
Swissprot #:
P18887
User NOte:
Optimal dilutions for each application to be determined by the researcher.