ACACA Antibody
| Code | Size | Price |
|---|
| PSI-58-978-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA
Application Note:
For WB starting dilution is: 1:1000
Background:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional
enzyme system. ACC is a biotin-containing enzyme which catalyzes
the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting
step in fatty acid synthesis. There are two ACC forms, alpha and
beta, encoded by two different genes. ACC-alpha is highly enriched
in lipogenic tissues. The enzyme is under long term control at the
transcriptional and translational levels and under short term
regulation by the phosphorylation/dephosphorylation of targeted
serine residues and by allosteric transformation by citrate or
palmitoyl-CoA. Multiple alternatively spliced transcript variants
divergent in the 5' sequence and encoding distinct isoforms have
been found for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2010-2039 amino acids from the C-terminal region of human ACACA.
NCBI Gene ID #:
31
NCBI Official Name:
Acetyl-CoA carboxylase 1
NCBI Official Symbol:
ACACA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
266 kDa
Protein Accession #:
Q13085
Protein GI Number:
118601083
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q13085
User NOte:
Optimal dilutions for each application to be determined by the researcher.