ALDOB Antibody
| Code | Size | Price |
|---|
| PSI-60-153-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB
Application Note:
For WB starting dilution is: 1:1000
Background:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a
tetrameric glycolytic enzyme that catalyzes the reversible
conversion of fructose-1,6-bisphosphate to glyceraldehyde
3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3
aldolase isozymes which are distinguished by their electrophoretic
and catalytic properties. Differences indicate that aldolases A, B,
and C are distinct proteins, the products of a family of related
'housekeeping' genes exhibiting developmentally regulated
expression of the different isozymes. The developing embryo
produces aldolase A, which is produced in even greater amounts in
adult muscle where it can be as much as 5% of total cellular
protein. In adult liver, kidney and intestine, aldolase A
expression is repressed and aldolase B is produced. In brain and
other nervous tissue, aldolase A and C are expressed about equally.
There is a high degree of homology between aldolase A and C.
Defects in ALDOB cause hereditary fructose intolerance. [provided
by RefSeq].
Background References:
- Bouteldja, N., et al. J. Inherit. Metab. Dis. 33(2):105-112(2010)
- Coffee, E.M., et al. J. Inherit. Metab. Dis. 33(1):33-42(2010)
- Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
- Davit-Spraul, A., et al. Mol. Genet. Metab. 94(4):443-447(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Immunogen:
This ALDOB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human ALDOB.
NCBI Gene ID #:
229
NCBI Official Name:
Fructose-bisphosphate aldolase B
NCBI Official Symbol:
ALDOB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
P05062
Protein GI Number:
113611
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P05062
User NOte:
Optimal dilutions for each application to be determined by the researcher.