HMGCL Antibody

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ProSci
Product Code: PSI-58-337
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-58-337-400ul400ul£626.00
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in WiDr cell line lysates (35ug/lane).
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Western blot analysis in WiDr cell line lysates (35ug/lane).

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Further Information

Additional Names:
Hydroxymethylglutaryl-CoA lyase, mitochondrial, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase, HMGCL
Application Note:
For WB starting dilution is: 1:1000
Background:
HMGCL belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Background References:
  • Fu, Z., et al. J. Biol. Chem. 285(34):26341-26349(2010)
  • Pierron, S., et al. Arch Pediatr 17(1):10-13(2010)
  • Menao, S., et al. Hum. Mutat. 30 (3), E520-E529 (2009) :
  • Lin, W.D., et al. Clin. Chim. Acta 401 (1-2), 33-36 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Immunogen:
This HMGCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the Central region of human HMGCL.
NCBI Gene ID #:
3155
NCBI Official Name:
Hydroxymethylglutaryl-CoA lyase, mitochondrial
NCBI Official Symbol:
HMGCL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
34 kDa
Protein Accession #:
P35914
Protein GI Number:
24418852
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P35914
User NOte:
Optimal dilutions for each application to be determined by the researcher.