PRKAG3 Antibody
| Code | Size | Price |
|---|
| PSI-58-783-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
5'-AMP-activated protein kinase subunit gamma-3, AMPK gamma3, AMPK subunit gamma-3, PRKAG3, AMPKG3
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a regulatory subunit
of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer
consisting of an alpha catalytic subunit, and non-catalytic beta
and gamma subunits. AMPK is an important energy-sensing enzyme that
monitors cellular energy status. In response to cellular metabolic
stresses, AMPK is activated, and thus phosphorylates and
inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy
beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in
regulating de novo biosynthesis of fatty acid and cholesterol. This
subunit is one of the gamma regulatory subunits of AMPK. It is
dominantly expressed in skeletal muscle. Studies of the pig
counterpart suggest that this subunit may play a key role in the
regulation of energy metabolism in skeletal muscle. [provided by
RefSeq].
Background References:
- Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
- Jassim, G., et al. Pharmacopsychiatry (2010) In press :
- Crawford, S.A., et al. Diabetologia 53(9):1986-1997(2010)
- Ramanathan, L., et al. Protein Expr. Purif. 70(1):13-22(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This PRKAG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-454 amino acids from the C-terminal region of human PRKAG3.
NCBI Gene ID #:
53632
NCBI Official Name:
5'-AMP-activated protein kinase subunit gamma-3
NCBI Official Symbol:
PRKAG3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
Q9UGI9
Protein GI Number:
85681287
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q9UGI9
User NOte:
Optimal dilutions for each application to be determined by the researcher.