EBP Antibody
| Code | Size | Price |
|---|
| PSI-60-650-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, Cholestenol Delta-isomerase, Delta(8)-Delta(7) sterol isomerase, D8-D7 sterol isomerase, Emopamil-binding protein, EBP
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is an integral membrane
protein of the endoplasmic reticulum. It is a high affinity binding
protein for the antiischemic phenylalkylamine Ca2+ antagonist
[3H]emopamil and the photoaffinity label [3H]azidopamil. It is
similar to sigma receptors and may be a member of a superfamily of
high affinity drug-binding proteins in the endoplasmic reticulum of
different tissues. This protein shares structural features with
bacterial and eukaryontic drug transporting proteins. It has four
putative transmembrane segments and contains two conserved
glutamate residues which may be involved in the transport of
cationic amphiphilics. Another prominent feature of this protein is
its high content of aromatic amino acid residues (>23%) in its
transmembrane segments. These aromatic amino acid residues have
been suggested to be involved in the drug transport by the
P-glycoprotein. Mutations in this gene cause Chondrodysplasia
punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Background References:
- Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
- Ausavarat, S., et al. EurDermatol 18(4):391-393(2008)
- Steijlen, P.M., et al. Br. J. Dermatol. 157(6):1225-1229(2007)
- Guggenberger, C., et al. J. Steroid Biochem. Mol. Biol. 104 (3-5), 105-109 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This EBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the C-terminal region of human EBP.
NCBI Gene ID #:
10682
NCBI Official Name:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
NCBI Official Symbol:
EBP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
Q15125
Protein GI Number:
17374795
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q15125
User NOte:
Optimal dilutions for each application to be determined by the researcher.