FH Antibody
| Code | Size | Price |
|---|
| PSI-59-859-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Fumarate hydratase, mitochondrial, Fumarase, FH
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is an enzymatic component
of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and
catalyzes the formation of L-malate from fumarate. It exists in
both a cytosolic form and an N-terminal extended form, differing
only in the translation start site used. The N-terminal extended
form is targeted to the mitochondrion, where the removal of the
extension generates the same form as in the cytoplasm. It is
similar to some thermostable class II fumarases and functions as a
homotetramer. Mutations in this gene can cause fumarase deficiency
and lead to progressive encephalopathy.
Background References:
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Allegri, G., et al. J. Inherit. Metab. Dis. 33(4):411-419(2010)
- Yogev, O., et al. PLoS Biol.(3), E1000328 (2010) :
- Yang, Y., et al. Cancer Genet. Cytogenet. 196(1):45-55(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Pig, Rat
Immunogen:
This FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the N-terminal region of human FH.
NCBI Gene ID #:
2271
NCBI Official Name:
Fumarate hydratase, mitochondrial
NCBI Official Symbol:
FH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
P07954
Protein GI Number:
1730117
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P07954
User NOte:
Optimal dilutions for each application to be determined by the researcher.