AKR1D1 Antibody
| Code | Size | Price |
|---|
| PSI-58-637-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1
Application Note:
For WB starting dilution is: 1:1000
Background:
The enzyme encoded by this gene is responsible for the
catalysis of the 5-beta-reduction of bile acid intermediates and
steroid hormones carrying a delta(4)-3-one structure. Deficiency of
this enzyme may contribute to hepatic dysfunction. Three transcript
variants encoding different isoforms have been found for this gene.
Other variants may be present, but their full-length natures have
not been determined yet.
Background References:
- Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :
- Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This AKR1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the Central region of human AKR1D1.
NCBI Gene ID #:
6718
NCBI Official Name:
3-oxo-5-beta-steroid 4-dehydrogenase
NCBI Official Symbol:
AKR1D1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
Protein Accession #:
P51857
Protein GI Number:
1703007
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P51857
User NOte:
Optimal dilutions for each application to be determined by the researcher.