ACER1 Antibody
| Code | Size | Price |
|---|
| PSI-60-034-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3
Application Note:
For WB starting dilution is: 1:1000
Background:
Ceramides are synthesized during epidermal differentiation
and accumulate within the interstices of the stratum corneum, where
they represent critical components of the epidermal permeability
barrier. Excess cellular ceramide can trigger antimitogenic signals
and induce apoptosis, and the ceramide metabolites sphingosine and
sphingosine-1-phosphate (S1P) are important bioregulatory
molecules. Ceramide hydrolysis in the nucleated cell layers
regulates keratinocyte proliferation and apoptosis in response to
external stress. Ceramide hydrolysis also occurs at the stratum
corneum, releasing free sphingoid base that functions as an
endogenous antimicrobial agent. ACER1 is highly expressed in
epidermis and catalyzes the hydrolysis of very long chain ceramides
to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun
et al., 2008 [PubMed 17713573]).
Background References:
- Sun, W., et al. J. Invest. Dermatol. 128(2):389-397(2008)
- Toulza, E., et al. Genome Biol.(6), R107 (2007) :
- Houben, E., et al. J. Lipid Res. 47(5):1063-1070(2006)
- Mao, C., et al. J. Biol. Chem. 278(33):31184-31191(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.
NCBI Gene ID #:
125981
NCBI Official Name:
Alkaline ceramidase 1
NCBI Official Symbol:
ACER1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
Q8TDN7
Protein GI Number:
74715919
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q8TDN7
User NOte:
Optimal dilutions for each application to be determined by the researcher.