NDUFV1 Antibody
| Code | Size | Price |
|---|
| PSI-60-532-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, Complex I-51kD, CI-51kD, NADH dehydrogenase flavoprotein 1, NADH-ubiquinone oxidoreductase 51 kDa subunit, NDUFV1, UQOR1
Application Note:
For WB starting dilution is: 1:1000
Background:
The mitochondrial respiratory chain provides energy to
cells via oxidative phosphorylation and consists of four
membrane-bound electron-transporting protein complexes (I-IV) and
an ATP synthase (complex V). This gene encodes a 51 kDa subunit of
the NADH:ubiquinone oxidoreductase complex I; a large complex with
at least 45 nuclear and mitochondrial encoded subunits that
liberates electrons from NADH and channels them to ubiquinone. This
subunit carries the NADH-binding site as well as flavin
mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I
are a common cause of mitochondrial dysfunction; a syndrome that
occurs in approximately 1 in 10,000 live births. Mitochondrial
complex I deficiency is linked to myopathies, encephalomyopathies,
and neurodegenerative disorders such as Parkinson's disease and
Leigh syndrome. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.
Background References:
- Wang, W., et al. Nucleic Acids Res. (2010) In press :
- Moran, M., et al. Biochim. Biophys. Acta 1802(5):443-453(2010)
- Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
- Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse
Immunogen:
This NDUFV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human NDUFV1.
NCBI Gene ID #:
4723
NCBI Official Name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
NCBI Official Symbol:
NDUFV1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Protein Accession #:
P49821
Protein GI Number:
20455501
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P49821
User NOte:
Optimal dilutions for each application to be determined by the researcher.