HDAC3 Antibody
| Code | Size | Price |
|---|
| PSI-56-975-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Histones play a critical role in transcriptional
regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and
affects transcription factor access to DNA. The protein encoded by
this gene belongs to the histone deacetylase/acuc/apha family. It
has histone deacetylase activity and represses transcription when
tethered to a promoter. It may participate in the regulation of
transcription through its binding with the zinc-finger
transcription factor YY1. This protein can also down-regulate p53
function and thus modulate cell growth and apoptosis. This gene is
regarded as a potential tumor suppressor gene. [provided by
RefSeq].
Background References:
- Minamiya, Y., et al. Tumour Biol. 31(5):533-539(2010)
- Kim, H.C., et al. Cell. Mol. Life Sci. 67(20):3499-3510(2010)
- Yang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :
- Kim, T., et al. Psychiatry Res 178(2):266-269(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This HDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the C-terminal region of human HDAC3.
NCBI Gene ID #:
8841
NCBI Official Name:
Histone deacetylase 3
NCBI Official Symbol:
HDAC3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
Protein Accession #:
O15379
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
O15379
User NOte:
Optimal dilutions for each application to be determined by the researcher.