ABCD2 Antibody
Code | Size | Price |
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PSI-56-546-400ul | 400ul | £626.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR, ABCD2, ALD1, ALDL1, ALDR, ALDRP
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the ALD subfamily, which is involved in
peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
organelle. All known peroxisomal ABC transporters are half
transporters which require a partner half transporter molecule to
form a functional homodimeric or heterodimeric transporter. The
function of this peroxisomal membrane protein is unknown; however
this protein is speculated to function as a dimerization partner of
ABCD1 and/or other peroxisomal ABC transporters. Mutations in this
gene have been observed in patients with adrenoleukodystrophy, a
severe demyelinating disease. This gene has been identified as a
candidate for a modifier gene, accounting for the extreme variation
among adrenoleukodystrophy phenotypes. This gene is also a
candidate for a complement group of Zellweger syndrome, a
genetically heterogeneous disorder of peroxisomal biogenesis.
Background References:
- Matsukawa, T., et al. Neurogenetics (2010) In press :
- Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
- Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008)
- Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.
NCBI Gene ID #:
225
NCBI Official Name:
ATP-binding cassette sub-family D member 2
NCBI Official Symbol:
ABCD2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
Q9UBJ2
Protein GI Number:
12643305
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q9UBJ2
User NOte:
Optimal dilutions for each application to be determined by the researcher.