ABCD1 Antibody
| Code | Size | Price |
|---|
| PSI-55-187-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP, ABCD1, ALD
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
ABCD1 is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the ALD subfamily, which is involved in
peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
organelle. All known peroxisomal ABC transporters are half
transporters which require a partner half transporter molecule to
form a functional homodimeric or heterodimeric transporter. This
peroxisomal membrane protein is likely involved in the peroxisomal
transport or catabolism of very long chain fatty acids. Defects in
this gene have been identified as the underlying cause of
adrenoleukodystrophy, an X-chromosome recessively inherited
demyelinating disorder of the nervous system.
Background References:
- Matsukawa, T., et al. Neurogenetics (2010) In press :
- Xie, H.H., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(2):144-148(2010)
- Li, J.Y., et al. J. Neurol. Sci. 290 (1-2), 163-165 (2010) :
- Hour, T.C., et al. Int. J. Biol. Markers 24(3):171-178(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
NCBI Gene ID #:
215
NCBI Official Name:
ATP-binding cassette sub-family D member 1
NCBI Official Symbol:
ABCD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
P33897
Protein GI Number:
67476960
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P33897
User NOte:
Optimal dilutions for each application to be determined by the researcher.