FOLH1 Antibody
| Code | Size | Price |
|---|
| PSI-57-212-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
This gene encodes a type II transmembrane glycoprotein
belonging to the M28 peptidase family. The protein acts as a
glutamate carboxypeptidase on different alternative substrates,
including the nutrient folate and the neuropeptide
N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of
tissues such as prostate, central and peripheral nervous system and
kidney. A mutation in this gene may be associated with impaired
intestinal absorption of dietary folates, resulting in low blood
folate levels and consequent hyperhomocysteinemia. Expression of
this protein in the brain may be involved in a number of
pathological conditions associated with glutamate excitotoxicity.
In the prostate the protein is up-regulated in cancerous cells and
is used as an effective diagnostic and prognostic indicator of
prostate cancer. This gene likely arose from a duplication event of
a nearby chromosomal region. Alternative splicing gives rise to
multiple transcript variants encoding several different isoforms.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Mlcochova, P., et al. Prostate 69(5):471-479(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat
Immunogen:
This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.
NCBI Gene ID #:
2346
NCBI Official Name:
Glutamate carboxypeptidase 2
NCBI Official Symbol:
FOLH1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Protein Accession #:
Q04609
Protein GI Number:
548615
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q04609
User NOte:
Optimal dilutions for each application to be determined by the researcher.