SFTPC Antibody
| Code | Size | Price |
|---|
| PSI-57-199-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Pulmonary surfactant-associated protein C, SP-C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5, SFTPC, SFTP2
Application Note:
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
Background:
This gene encodes the pulmonary-associated surfactant
protein C (SPC), an extremely hydrophobic surfactant protein
essential for lung function and homeostasis after birth. Pulmonary
surfactant is a surface-active lipoprotein complex composed of 90%
lipids and 10% proteins which include plasma proteins and
apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted
by the alveolar cells of the lung and maintains the stability of
pulmonary tissue by reducing the surface tension of fluids that
coat the lung. Multiple mutations in this gene have been
identified, which cause pulmonary surfactant metabolism dysfunction
type 2, also called pulmonary alveolar proteinosis due to
surfactant protein C deficiency, and are associated with
interstitial lung disease in older infants, children, and adults.
Alternatively spliced transcript variants encoding different
protein isoforms have been identified.
Background References:
- Wambach, J.A., et al. Pediatr. Res. 68(3):216-220(2010)
- Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
- Thouvenin, G., et al. Arch. Dis. Child. 95(6):449-454(2010)
- Crossno, P.F., et al. Chest 137(4):969-973(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SFTPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human SFTPC.
NCBI Gene ID #:
6440
NCBI Official Name:
Pulmonary surfactant-associated protein C
NCBI Official Symbol:
SFTPC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
Protein Accession #:
P11686
Protein GI Number:
131425
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P11686
User NOte:
Optimal dilutions for each application to be determined by the researcher.