SPNXB Antibody
| Code | Size | Price |
|---|
| PSI-60-946-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Sperm protein associated with the nucleus on the X chromosome B/F, Cancer/testis antigen 112, CT112, Nuclear-associated protein SPAN-Xb, SPANX-B, Nuclear-associated protein SPAN-Xf, SPANX-F, SPANX family member B/F, SPANXB1, SPANXB
Application Note:
For WB starting dilution is: 1:1000
Background:
Temporally regulated transcription and translation of
several testis-specific genes is required to initiate the series of
molecular and morphological changes in the male germ cell lineage
necessary for the formation of mature spermatozoa. This gene is a
member of the SPANX family of cancer/testis-associated genes, which
are located in a cluster on chromosome X. The SPANX genes encode
differentially expressed testis-specific proteins that localize to
various subcellular compartments. This particular gene maps to
chromosome X in a head-to-tail orientation with SPANX family member
B1 and appears to be a duplication of that locus. The SPANXB genes
are unique members of this gene family, since they contain an
additional 18 nt in their coding region compared to the majority of
family members. Although the protein encoded by this gene contains
consensus nuclear localization signals, the major site for
subcellular localization of expressed protein is in the cytoplasmic
droplets of ejaculated spermatozoa. This protein provides a
biochemical marker for studying the unique structures in
spermatazoa, while attempting to further define its role in
spermatogenesis.
Background References:
- Hansen, S., et al. Syst Biol Reprod Med 55, 18-26 (2010) :
- Hansen, M.A., et al. Mol. Reprod. Dev. 75(2):219-229(2008)
- Kouprina, N., et al. Genome Res. 15(11):1477-1486(2005)
- Ross, M.T., et al. Nature 434(7031):325-337(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SPNXB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the Central region of human SPNXB.
NCBI Gene ID #:
728695
NCBI Official Name:
Sperm protein associated with the nucleus on the X chromosome B/F
NCBI Official Symbol:
SPANXB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
12 kDa
Protein Accession #:
Q9NS25
Protein GI Number:
85700153
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q9NS25
User NOte:
Optimal dilutions for each application to be determined by the researcher.