RASA1 Antibody
| Code | Size | Price |
|---|
| PSI-56-754-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ras GTPase-activating protein 1, GAP, GTPase-activating protein, RasGAP, Ras p21 protein activator, p120GAP, RASA1, GAP, RASA
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is located in the
cytoplasm and is part of the GAP1 family of GTPase-activating
proteins. The gene product stimulates the GTPase activity of normal
RAS p21 but not its oncogenic counterpart. Acting as a suppressor
of RAS function, the protein enhances the weak intrinsic GTPase
activity of RAS proteins resulting in the inactive GDP-bound form
of RAS, thereby allowing control of cellular proliferation and
differentiation. Mutations leading to changes in the binding sites
of either protein are associated with basal cell carcinomas.
Alternative splicing results in two isoforms where the shorter
isoform, lacking the N-terminal hydrophobic region but retaining
the same activity, appears to be abundantly expressed in placental
but not adult tissues.
Background References:
- Hemerly, J.P., et al. Eur. J. Endocrinol. 163(5):747-755(2010)
- Wiemels, J.L., et al. Blood Cells Mol. Dis. 45(3):186-191(2010)
- Bachas, C., et al. Blood 116(15):2752-2758(2010)
- Oinuma, I., et al. J. Biol. Chem. 285(36):28200-28209(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This RASA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 966-993 amino acids from the C-terminal region of human RASA1.
NCBI Gene ID #:
5921
NCBI Official Name:
Ras GTPase-activating protein 1
NCBI Official Symbol:
RASA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
116 kDa
Protein Accession #:
P20936
Protein GI Number:
121743
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P20936
User NOte:
Optimal dilutions for each application to be determined by the researcher.